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KMID : 0881720100250030263
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Journal of Food Hygiene and Safety
2010 Volume.25 No. 3 p.263 ~ p.268
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Toxicity Study of Detoxication Sulphur at 3 Months Post-treatment in Rats
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Lee Jin-Seok
Kwon Jung-Ki
Han Sang-Hyeon
An In-Jung
Kim So-Jeong
Lee Seung-Ho
Park Young-Seok
Park Byung-Kwon
Kim Byeong-Soo
Kim Sang-Ki
Kim In-Ho
Choi Chang-Sun
Jung Ji-Youn
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Abstract
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This study was demonstrate a repeated oral dose toxicity of detoxication sulphur in 8-weeks-old female Sprague-Dawley (SD) rats. The rats were treated with dose of 0.2%, 1%, 5% detoxication sulphur and 1% sulphur of feed consumption administered for 13 weeks. To evaluate the safety of detoxication sulfur, we examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the hematological and the serum biochemical analysis. We also observed the histopathological changes of liver and kidney in rats. As a result, no significant differences in body weight, feed intake, hematological examination and histopathological between control and detoxication sulphur treatment group were found. Serum biochemical results were not shown significant differences in 0.2% and 1% the treated groups compared with control group. But glucose level were decrease, also ALT and ALP level were increase in 5% treated group. All of these results indicate that 1% detoxication sulphur of feed consumption may be safety in SD rat.
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KEYWORD
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Detoxication Sulphur, Toxicity
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